Pilot Plant

Leaving drug discovery and moving to scale up and pilot plant applications often means larger batch sizes and higher quantity of API being manipulated. For high potency applications especially, the quantity of powder can make a low toxicity drug a major threat to safety. Introducing larger and higher capacity equipment such as blenders, lyophilizers and ovens requires an evaluation of the risk assessment to insure personnel and/or product safety.

Class I BSC – Dual HEPA

Top Mount Containment ETA Series VBE, CVE, Class I Bio Safety Cabinet • Designed for working with balances and other equipment• Available in many exhaust configurations• Vibration reduction technology for reproducibility and accuracy• Acrylic Construction with Phenolic Resin Base PERFORMANCE TESTING Performance is paramount in the safety industry. Through consistent design quality and expert manufacturing, …

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N15 Weight Sorter Enclosure

DESCRIPTION Top-mounted enclosure with BIBO filtration designed to house N15 Weight Sorter. Unit features port for continuous liner and a waste chute. Acrylic structure improves visibility within the workspace, while hinged front door facilitates operator access to application. Size:48” External Width30” External Depth32” Internal Height PERFORMANCE TESTING Performance is paramount in the safety industry. Through …

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SP Scientific Lyostar II Freeze Drying Glovebox

DESCRIPTION SP Scientific LyoStar II Freeze Drying Glovebox designed to provide product and personnel protection while working with liquid substances. The enclosure features include polypropylene superstructure, inlet HEPA filtration, dished black phenolic base, top mount fans with HEPA, pressure differential gauge, thimble connections, vent kit, flashing safety light, internal pass thru with flange connection, ELC …

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HPAPI Processing and Drying Suite

HPAPI Processing & Drying Suite DESCRIPTION HPAPI Processing and Drying Suite designed as a complete process system with 2 glovebox enclosures connected for processing and drying of HPAPI (High Potency Active Pharmaceutical Ingredients). Designed specifically for the use of a Binder VDL115 oven. The suite features include flame retardant polypropylene superstructures, central transfer port, inlet …

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Fitzmill L1A & Quadro Comil Glovebox

Glovebox Workstation Glovebox and Comil Glovebox and Fitzmill DESCRIPTION Negative pressure unit designed to contain Fitzmill L1A and Quadro Comil U5 R&D mills for operator protection while working with powder substances. Enclosure equipped with waste chute and pass through interlocking chamber for loading and unloading materials on left side of unit as well as 5 …

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Polypropylene Bulk Powder Enclosure

Bulk Powder enclosure with Bag-In/Bag-Out HEPA filtration system designed for weighing application using an Avery Weigh-Tronix Digital Bench Scale. Enclosure includes stainless steel lift cart and is fitted with 20” base cutout for loading/unloading bulk drums. Hinged front doors provide easy access to application and protection from exposure to hazardous APIs. Airfoils, rear plenums, fan …

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Buchi B-290 Mini-Spray Dryer Enclosure for API Processing

Purpose: Flow Sciences was approached to design and build an enclosure that could house the Buchi B-290 Mini-Spray Dryer during process. Particle sizes would range from 1 to 25 µm, requiring the enclosure to offer containment down to less than one microgram per cubic meter. The client planned to weigh API and dissolve weighed sample …

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Dual Operator GloveBox Workstation with Balance

DESCRIPTION Dual Operator Glovebox Workstation with Balance Enclosure is designed to contain a process applicaiton where both weighing in an open faced enclosure and working with a reactor in a clean air environment are needed.  The weighing portion of the unit is designed to contain a Mettler-Toledo XS204 balance.  This weighing unit is connected to …

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Sieving Suite

Sieving Suite Hybrid Isolator designed to house Retsch AS-200 TAP Sieve Shaker and Hirschmann Laborgeräte Jolting Volumeter STAV-II with Water bath cart. Airfoils and plenums coupled with a Dual HEPA filtration and BIBO system control airflow across the workstation and maximize personnel protection while working with powder APIs. Stainless steel construction with inset acrylic paneling …

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Hybrid Isolator

Dual Purpose Glovebox & Vented Enclosure Contact Our Experts Process Weighing, dispensing, dissolution, compound, or handling of APIs and/or HPAPIs where personnel protection is required. Containment Dependent on potency and quantity of the toxic material being processed, this unit can contain to nanogram levels and from OEB 3–5. Design Provides adequate containment for a variety …

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Glovebox Workstation

Glovebox Workstation LFBC™ Lateral Flow Bio Containment Isolator for HPAPI Processing Contact Our Experts Today Process Weighing, dispensing, dissolution or handling of APIs and/or HPAPIs where personnel protection is required. Containment Reaches containment measured in nanogram levels and from OEB 3–5, depending on application and quantity. Design Provides adequate containment for equipment including balances, ovens, …

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API WEIGHING & SOLID DOSING SUITE

API Weighing and Solid Dosing Suite

Performance Testing Results Containment Target : 10 ng/m³Surrogate Powder Testing Result :  2.26 ng/m³ Equipment : Balance, VialsOperation : Weighing, Dissolution, DispensingTest : Naproxen Sodium – 3 x 20mg API Weighing and Solid Dosing Suite designed to provide personnel protection and product protection during the weighing of API powder and subsequent dosing (dose allocation) of …

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Analytical Process Isolator

Virus Screening & HPAPI Handling-The Analytical Process Isolator

Analytical Process Isolator™ Continuous Process Isolator for Virus Screening & HPAPI Handling Contact Our Experts Process Allows for ISO 5 processing and intake/outtake through a negative pressure cabinet. Containment Surrogate powder test results show containment below 10 ng/m3, even with large spills.  Design The chamber on the right is a vented balance enclosure (VBE) for …

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Fitzmill L1A & Quadro Comil Glovebox

Glovebox Workstation Glovebox and Comil Glovebox and Fitzmill Process:Flow Sciences was approached to design a glovebox that would enclose milling processes done by either a Fitzmill L1A or a Quadro Comil. Containment Design:A panel interface on the right side of the glovebox allowed for the connection of either piece of equipment that would sit on …

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Memmert VO 200 Vacuum Oven Enclosure

Memmert VO 200 Vacuum Oven Enclosure          Finding a solution to provide personnel protection when working with Highly Potent Active Pharmaceutical Ingredients (HPAPI) is very tricky. In a business sector where regulations and policies are prevalent, exposure control options are limiting; both physically and financially. Laboratory operations require unwavering precision and physical/financial …

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Genevac EZ2 Elite Evaporator and Powder Handling Suite

Genevac EZ2 Elite Evaporator and Powder Handling Suite             Flow Sciences, Inc. was tasked with designing a modular containment unit that would house a Genevac EZ2 Elite Evaporator and allow for transfer of materials post-manipulation into a separate, connected balance enclosure for weighing. The Genevac equipment required a level, sturdy work surface and a 2” …

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