Press Releases

Flow Sciences, Inc. Supplies 10 Enclosures for High Capacity COVID-19 Testing

Personnel protection was required while processing virus samples

LELAND, NC (June 17, 2020) – Flow Sciences, Inc., a leading global provider of containment solutions, recently worked with Sema4, a patient-centered health intelligence company, to provide enclosures designed to protect its laboratory personnel while processing patient samples for COVID-19. Due to the crucial nature of Sema4’s work, Flow Sciences designed, engineered, tested, and delivered all ten enclosures to Sema4’s laboratory in Branford, CT within four weeks.

Flow Sciences constructed a polypropylene-framed enclosure with removable panels for equipment loading. A Dual HEPA Bag-in/Bag-out fan and filter system would clean the workspace air and allow for recirculation back into the laboratory. The customized enclosure was modeled around the JANUS G3 liquid handler with a waste chute was fitted in the base. The JANUS G3 primary sample reformatter provides safe and traceable barcode scanning and reformatting of up to 192 input biological samples from nasopharyngeal and oropharyngeal swabs into various destination labware to support viral nucleic acid extraction. The Janus G3 can be loaded with samples, closed within the enclosure, and then run using exterior controls—allowing the personnel to safely “walk away” while sample manipulation occurs. A monitor mount and sliding keyboard tray was constructed for ease of use with the JANUS G3 on the FSI unit’s custom table. The operator does not have to slide the acrylic door of the enclosure open to remove samples until the cycle is complete—isolating personnel as requested. Any maintenance on the unit can be done by way of removable acrylic side panels which allow access to the sides and rear of the unit without removing the Janus G3 from the enclosure.

Sema4 needed enclosures from Flow Sciences as it expanded its COVID-19 viral testing capacity to 10,000 tests per day and launched antibody testing, with the ability to process 5,000 tests per day. Sema4 is providing an end-to-end digital solution for those ordering and receiving COVID-19 tests, including portals for registering employees and patients, tracking samples, and reporting results.

“Our team recognized the importance of Sema4’s work on this terrible virus, so we prioritized the design and delivery of these enclosures,” says Ray Ryan, President and CEO of Flow Sciences, Inc. “We consider our inclusion in this project as a big step forward in the fight against COVID-19.”

For more information about Sema4’s COVID-19 offerings, please visit https://sema4.com/covid19-testing.

For more information about FSI’s custom enclosure capabilities, please visit http://www.flowsciences.com or call us at 1-800-849-3429


FLOW SCIENCES VIRTUAL SHOWROOM: BULK POWDER HYBRID ISOLATOR

 

Our next virtual webinar will be held on

 

May 7 at 2:00 PM EST

 

 Bulk powder handling inside an FSI Hybrid Isolator offers containment for OEB 3-5.

We will be discussing high potency bulk powder handling within our Hybrid Isolators.

The presentation will be a live video of the Isolator in our laboratory with a live Q&A to follow.

 

Click here to register now!

 

Bulk Powder Containment: Key Factors for High Potency Handling and Processing

 

Bulk Powder Hybrid Isolator

Recently, pharmaceutical facilities have seen an increase in new API’s. These newer powerful drug ingredients have reached a potency where containment equipment requirements have reached a much more demanding level. Read More

For more information or to get a quote today,
call 1-800-849-3429

FLOW SCIENCES INC PREMIERES VIRTUAL SHOWROOM

FSI welcomes you to participate in our inaugural
Virtual Showroom on April 2

(LELAND, NC) MARCH 26, 2020 – Flow Sciences, a leading global provider of containment solutions, is bringing you 30+ years of containment expertise to a series of webinars in our new Virtual Showroom. Due to shutdowns caused by COVID-19, manufacturing sites and corporate offices are closed to visitors, and tradeshows/conferences are being cancelled or postponed.

Flow Sciences will be conducting a series of Product Premieres, Training Sessions, Live Q&As, Webinars and more that can be accessed remotely. There is no travel or cost required—all that is needed is an internet connection and a phone, tablet, or computer.

FSI's premiere Virtual Showroom session will be live on

April 2, 2020 at 2:00PM EST

A brief Q&A session will follow the presentation.

Click here to register now

FSI’s EGP/EGG Series of Glovebox Workstation

For our inaugural webinar we will go in-depth about the features of benefits of FSI’s EGP/EGG Series of Glovebox Workstations. The GBWS is an LFBC™ (Lateral Flow Bio Containment Isolator) for HPAPI Processing.

The Glovebox Workstation series provides containment for highly toxic applications using APIs that need more safety than an opened face enclosure. FSI engineering controls are built in to prevent loss of containment. Third Party testing has proven containment on these units to below 30 ng/m³ based on process and quantity.

We will be exploring its capabilities, features, and standard options, as well as answering your questions.

Join us tomorrow, April 2 at 2:00 PM EST to see the Glovebox Workstation.


Analytical Process Isolator

Virus Screening & HPAPI Handling-The Analytical Process Isolator

ANALYTICAL PROCESS ISOLATOR


Continuous Process Isolator for Product & Personnel Protection

The Analytical Process Isolator™ or A.P.I. is a continuous process isolator to vented enclosure system that allows for ISO 5 clean processing and intake or outtake through a negative pressure vented cabinet.

 

  •  Proprietary Lateral Flow Bio Containment™ LFBC™ ISO 5 Lateral Flow Interior Glove Box Isolator for Personnel & Product Protection
  •  Vented Enclosure with Negative Pressure Connected through a proprietary space-saving Door Design for Secondary Cleaning or Decontamination
  •  Lateral Flow or Smooth Horizontal Airflow Across the Isolator Prevents Disturbance on the Work Surface or When Sampling
  •  4″ Pleated HEPA Inlet filter, as well as Dual HEPA BIBO (Bag-In/Bag-Out) Exhaust Stacks on the Isolator Side and Vented Enclosure Side Allow for Recirculation of Clean Air into the Lab
  •  Without Customization, the Analytical Process Isolator has an 8-10 WEEK Lead Time
  •  Surrogate Powder Test Results show Proven Containment Below 10 ng/m3, Even with Catastrophic Spill

 

Sample Application:  Highly Potent API Weighing & Sampling
Weighing and solution prep with 10g of OEB 5 powder, then transfer into vented enclosure for secondary cleaning. Containment Performance Target: to work with the OEB 4 and OEB 5 APIs, the customer required 10ng/m3 (ten nanograms per meter cubed) at the breathing zone of the operator, as well as ISO 5 or better interior cleanliness.

 

Sample Application:  High Throughput Virus Screening
Screening or PCR of 96 well plate of virus samples in a dual protection (product & personnel protection) isolator.  The ISO 5 interior cleanliness keeps the integrity of the samples, while the less than 10 ng/m3 containment ensures safety for the operator. Containment Performance Target: Product and Personnel Protection while sampling highly potent or toxic materials, including infectious virus screening.


Contact Flow Sciences for More Information

  • What is being done inside of the enclosure? What type of material (powder, liquid, gas, nuisance odor) is being worked with? How does the material enter and exit the enclosure system? etc...
  • What type of filtration is required? Single HEPA, Dual HEPA, Carbon, House Exhaust, etc... What is the required OEL (Occupational Exposure Limit) for the process, or any other details about containment goals? What is the quantity of powder or liquid, task duration, composition of powder, etc...?
  • What equipment is being worked with? What is the equipment model, size, scope, function, and any other information that will affect the design of the enclosure, including movement, heat output, etc...? *State the specific equipment make and model if available*
  • Are there any additional notes or information that should be considered? Are there any special design requirements?

Plastic Ocean Project Teams with Flow Sciences, Inc. for Laboratory Research

LELAND, NC (FEBRUARY 18, 2020) – The Plastic Ocean Project (POP), an initiative that aims to educate about the dangers of plastic pollution, approached Flow Sciences, Inc., a leading provider of containment systems for HPAPI processing and ADC manufacturing, to create a sample protection solution during micro-fiber analysis. POP has been collecting ocean samples that needed to be analyzed within an enclosure capable of reducing the potential of cross-contamination from external sources. The collected samples are examined and sorted within the enclosure where the downflow from the FSI enclosure creates a clean space.  Reduction of the possibility of cross contamination from external sources makes their findings easier to publish in peer review journals.

POP’s mission is to the change the way the local community thinks about plastic, particularly with regards to its pollutant properties. By collecting contaminated ocean samples, POP is able to utilize FSI’s enclosures for its continuing research. The enclosure FSI provided POP was a top-mount ETA in a downflow configuration. This enclosure pushes room air through a 99.99% efficient HEPA filter into the enclosure, so that outside contamination of the lab does not affect the properties of the collected ocean samples being analyzed for harmful plastic microfibers.

Upon completion of the enclosure, POP was invited from its Wilmington office to visit the Flow Sciences testing lab in Leland, allowing the POP team to see how the unit should be properly used, and how successfully the enclosure provides a clean space for continuing POP’s research.

“We are extremely pleased with the performance of the unit Flow Sciences so graciously provided us for our research,” said Bonnie Monteleone, Director of Science, Research and Academic Partnerships for Plastic Ocean Project, Inc. “This will allow our research to reach a wider audience that is unaware of plastic pollution and how it affects not only our immediate community, but all the communities of this planet.”

For more information about the Plastic Ocean Project, visit http://www.plasticoceanproject.org

For more information about Flow Sciences, Inc. and its containment enclosure capabilities, visit http://www.flowsciences.com


FSI and IsoTech Enter Strategic Alliance for Non-Sterile and Sterile Containment


Flow Sciences Inc., Leland, NC and Isotech Design, Montreal (Quebec) Canada announce the formation of a strategic business alliance. This will promote the sales of one another’s products in North America and internationally to provide non-sterile and sterile solutions to pharma, biopharma, nanotechnology, pharmacy, and other industries.

Flow Sciences, Inc., a recognized thought leader in the production of containment devices for use in the processing of API and HPAPI powders during research, pilot plant and C-GMP manufacturing. See flowsciences.com

Isotech Design is a well-known quality leader in the design &production of barrier isolation technology & primary engineering controls used in aseptic compounding & production for pharmacies and pharmaceutical manufacturers. See www.isotechdesign.com

The companies will share booth space at the Interphex exhibition in New York City on April 2ndthru 4thand at the CPhI exhibition in Chicago on April 30ththru May 2nd. Their products will be on display and technical representatives will be able to answer questions and provide  support.



Less Downtime, More Productivity: FSI Systems Cost of Ownership

 

Flow Sciences, a leading provider of containment systems for laboratory, pilot plant, and manufacturing facilities, delivers low cost of ownership and high return on investment. By utilizing sophisticated engineering and design into the construction of the systems, they are able to achieve less lab downtime, more consistent results, no cross-contamination, and less energy consumption.

Q: How does Flow Sciences, Inc. (FSI) achieve lower cost of ownership?

A:All aspects of the systems are engineered to ensure consistent containment for the life of the enclosure, including materials of construction and modular design.  To begin, containment and safety is more important than filter change sales, and the 4” HEPA filters provide less lab downtime to our customers, besides the additional costs of the replacement filter and certification, which is timely and expensive.

Q: What HEPA filters does FSI use, and why?

A:The FSI HEPA filters are 4” pleated with a filter life of 4-5 years, eliminating the need to replace thinner filters frequently.  The airflow inside of the unit is most important. Often with filters you will see powder loading in a “hot spot” if the particulate is not spread evenly across the filter surface.  FSI hoods are designed with airfoils and internal plenums (baffles) to direct laminar airflow across the work surface.  However, the ceiling plenum itself evenly distributes the powder across the area of the filter.  When this occurs, the filter loads evenly and lasts much longer.

Q: Why is laminar airflow on the work surface important to cost of ownership?

A:Many powder applications rely on balance stability and accurate weighing to ensure reproducibility and results, resulting in less process time, which means less cost per sample.  Laminar airflow allows for improved balance stability and consistent sample weighing and manipulation.  Balances and other equipment may also be affected by vibration, which is a major concern in safety hoods.

Q: How does Flow Sciences reduce the vibration on the work surface of the hood?

A:Engineering controls isolate the vibration of the fan and create a stable work surface for balances and equipment, as well as the area around the enclosure if it is on a work bench.  We have videos on our website showing the testing with an accelerometer as well as balance stability to 6 or 7 places depending on the system.

Q: Does laminar airflow require more air volume?

 

A: Quite the inverse, actually.  FSI hoods lead the industry in containment while requiring less air and lower required face velocities.  Less air means less energy and results in cost savings, especially when the hood is connected to house exhaust.


GET A QUOTE

  • What is being done inside of the enclosure? What type of material (powder, liquid, gas, nuisance odor) is being worked with? How does the material enter and exit the enclosure system? etc...
  • What type of filtration is required? Single HEPA, Dual HEPA, Carbon, House Exhaust, etc... What is the required OEL (Occupational Exposure Limit) for the process, or any other details about containment goals? What is the quantity of powder or liquid, task duration, composition of powder, etc...?
  • What equipment is being worked with? What is the equipment model, size, scope, function, and any other information that will affect the design of the enclosure, including movement, heat output, etc...? *State the specific equipment make and model if available*
  • Are there any additional notes or information that should be considered? Are there any special design requirements?

Flow Sciences, Inc. Partners with Three Companies to Contain Lyophilization Process of New HPAPI

LELAND, NC, January 14, 2019 — On December 19, 2018; Allan W. Ader, Ph.D. (Safebridge Consultants, Inc.), and Richard Hirsh, CIH (Nektar Therapeutics) conducted a presentation along with Allan Goodman, Ph.D. and Stephen Janz of Flow Sciences, Inc. (FSI).

The presentation detailed the performance validation process of a Flow Sciences enclosure which was designed to protect Nektar Therapeutics personnel during the freeze-drying of powdered High Potency Active Pharmaceutical Ingredients (HPAPI) using the SP Scientific Virtis Advantage Pro. The presentation outlined the collaborative validation of enclosure containment performance between factory acceptance testing and site acceptance testing by Safebridge.

Since the respiratory-toxicological impacts of the HPAPI were not yet analyzed, Nektar Therapeutics utilized Safebridge Consultants, Inc. resources to develop an Occupational Health Categorization (or exposure band) for the substance. Flow Sciences consulted with SP Scientific to design an enclosure that accommodated the size of the Virtis Advantage Pro as well as space necessary for the safe cleanup of product in the event of a spill. During factory acceptance testing, FSI empirically verified containment performance through surrogate powder testing. During site acceptance testing, enclosure performance was put to the test through respiratory exposure sampling during a catastrophic-spill simulation. Sampling results from surrogate powder testing and the spill simulation indicated sampled respiratory exposure concentrations to be lower than laboratory reporting limits.

In summary, the multi-corporate effort of the project resulted in successful containment of a Lyophilization process to a concentration result of 1 microgram HPAPI per cubic meter of air (1 ug/m3).

If you would like more information regarding this collaborative performance validation between manufacturer, industrial hygiene consulting firm, and client; please download a copy of the presentation at the following link:

Case Study for Containment of High Potency Active Pharmaceutical Ingredients (HPAPI) in the Freeze Drying Process.


Products Featured:

For More information, contact Flow Sciences at 1-800-849-3429 or complete the form below


FSI Testing Performance - Laboratory Testing Services

LELAND, NC, December 18, 2018 —Flow Sciences, Inc. (FSI) evaluates and ensures that every enclosure shipped to their customer meets all relevant standards. FSI performs procedures from the American Society of Heating, Refrigeration, and Air Conditioning Engineers (ASHRAE) 110-2016 – Methods of Testing Performance of Laboratory Fume Hoods. Examples of testing procedures include flow visualization (local and large-volume challenges), tracer gas exposure modeling via human as mannequin (HAM) testing. These procedures are conducted in-house as Flow Sciences’ Factory Acceptance Testing (FAT). FAT testing is analogous to the “as manufactured” (AM) test as mentioned in ASHRAE 110-2016. Additionally, testing is conducted at the customer’s location upon request. This test is analogous to the “as installed” (AI) test. Flow Sciences, Inc. refers to this this test as the “SAT”, or Site Acceptance Test.

Aside from ASHRAE testing methodologies, Flow Sciences tests other functionalities of containment devices; one example is vibration isolation. During this test, vibration is purposefully initiated and its effect on the measurement of the balance is analyzed in accordance with Flow Sciences’ data reproducibility standards. In essence, the enclosure’s capability of isolating a balance from vibrational interferences stemming from the external environment is put to the test. Additional information regarding vibrational interferences can be found here.

For High Potency Active Pharmaceutical Ingredient (HPAPI) powder enclosures, FSI conducts surrogate powder testing to quantitatively assess containment performance. During the test, samples are collected using standard industrial hygiene field sampling methods. Following the test, samples are sent to a third-party analytical laboratory accredited by the American Industrial Hygiene Association Laboratory Accreditation Program (AIHA-LAP). Third-party IH companies can also be employed to perform the evaluation in FSI’s test facility.

For more information, please email your inquiry to info@flowsciences.com


Performance Validation by Third Party Industrial Hygienists


Flow Sciences, a leading provider of containment solutions for laboratory, pilot plant, and manufacturing facilities consults with third party industrial hygienists to conduct in-house Factory Acceptance Tests (FATs) and Site Acceptance Tests (SATs) to ensure customers’ products perform at the level they need.

Flow Sciences partners with experienced third-party Industrial Hygiene (IH) consulting professionals from partnering companies to verify the containment performance of an enclosure using the following standardized testing methodologies:

 

  1. Surrogate Powder Testing at Flow Science’s Laboratory

 

Following IH consultation, Flow Sciences conducts personal and area air sampling inside our in-house laboratory following thorough decontamination. Air samples are run while demonstrators perform a mock task with little instruction and then submitted for AIHA Lab Accreditation Program (LAP) approved analysis. Finally, Flow Sciences’ team of scientists and engineers analyzes the resulting data and determines if the enclosure performs better than its Containment Performance Target (CPT).  Many customers choose to use their own operators and are invited to observe and participate in the testing at Flow Sciences.

 

  1. Surrogate Powder Testing at Client Site

 

If the customer requests an SAT, Flow Sciences utilizes staff from an IH company to perform the same testing methods as the FAT. However, the test is performed at the customer site. This testing option affords the customer the opportunity to verify the performance of their enclosure by having the test conducted using their own Standard Operating Procedures (SOPs) and employees.

 

  1. ASHRAE-110and ANSI/AIHA Z9.5 – Laboratory Ventilation

 

In accordance with the previously mentioned methodologies, Flow Sciences conducts Average Airflow Velocity Measurements, Flow Visualization, Large Volume Smoke, Tracer Gas, and Surrogate Gas testing. Flow Sciences utilizes consultation from IH consulting professionals to design a sampling protocol to model employee exposure in the field.

 

For more information, visit flowsciences.com/testing/

To view more testing results, visit flowsciences.com/performance/


CAMERON FAULCONER, IH-MESH
Industrial Hygienist / Product Manager

Cameron Faulconer is an Industrial Hygienist with a wide breadth of experience, spanning between commercial manufacturing, to home residences. His inspiration for his choice of career is communicating the value of preserving the health and safety of employees using the most effective and efficient means possible. Therefore, Mr. Faulconer found his place in the “Engineering Controls” rung of the hierarchy of hazard controls.

As a problem solver, Mr. Faulconer believes that the best safety solutions are created through consultative conversations with those who seek solutions. He believes communicating information derived from these conversations to be critical to the continued understanding of the toxicological impacts of the work environment.

His personal motto is “protecting the safety and health of employees from what can and cannot be seen with the naked eye”.


Flow Sciences’ Glove Boxes Contain to Sub-Nano Levels

LELAND, NC, November 1, 2018 — Flow Sciences, a leading provider of containment systems for laboratory, pilot plant, and manufacturing facilities has recently proven through third-party acceptance testing that their gloveboxes can facilitate an interior concentration of less than 1 ng/m3.

The enclosures are designed to contain antibody drug conjugate (ADC) powder during the manufacturing of pharmaceuticals using highly potent active pharmaceutical ingredients. The level of containment for the Cytotoxic Drug Development Glovebox is .12 ng/m3, or 120 picograms per cubic meter (pg/m3). An acceptance testing result in this order of magnitude marks an impressive new chapter in the industry of containment enclosures.

At this point in time, it is difficult to predict what opportunities this innovation will bring to the market. As the size of powdered particles continue to decrease, Flow Sciences now provides containment solutions to future proof your facilities for the anticipated, upcoming needs for efficient and effective containment at the Sub-Nano level.

As it currently stands, control banding is a method used in the interim to account for the uncertainty that exists regarding engineered nanomaterials exposure. End users of Flow Sciences products can now seize the opportunity to expand their control bands into the picogram range.

Flow Sciences understands that standardized, validated, and specific methods for measuring personnel exposure to engineered nanomaterials (ex. breathing-zone measurements) are not currently available.* Therefore, Flow Sciences devotes their efforts to developing engineering controls to help make the collection of formative data more feasible.


Flow Sciences Speaks on Toxic Exposure at APG Fall Tech Expo


Are You Safe from Toxic Exposure?


Leland, NC – Flow Sciences, Inc. – On Wednesday, October 24, 2018, Flow Sciences attended the Aberdeen Proving Grounds Fall Technology Expo in Aberdeen, MD.Steve Janz and Josh Hutson of Flow Sciences were fortunate to have the opportunity to conduct a presentation entitled “Topics in Potent Compound Containment”.

Potent compounds are active ingredients with exposure risks to people and the environment. What should be considered when working with Potent Compounds?

  • Handling challenges
  • Specialized containment
  • Protecting the individual and environment from exposure

Flow Sciences Inc., the U.S. SBA 2018 North Carolina Exporter of the Year, has developed an industry leading reputation locally and around the world for safety and containment of handling toxic and hazardous materials.  They have 30+ years of experience with:

  • Top design workstations and enclosures
  • Cost effective equipment
  • Highly experienced Engineers, Scientists & Technicians
  • Quality and Safety of their products

 

For more information on Flow Sciences Inc. and their products, please visit: https://flowsciences.com/

 

If you are interested in receiving a copy of the presentation, please contact information@flowsciences.comor call 1-800-849-3429.


The Flow Sciences Advantage

PRESS RELEASE

Contact: Flow Sciences, Inc.

Tel: (800) 849-3429

Fax: (910) 763-1220

 

 FOR IMMEDIATE RELEASE

The Flow Sciences Advantage

LELAND, NC, June 19, 2018 — Flow Sciences, a leading provider of containment systems for laboratory, pilot plant, and manufacturing facilities offers an unparalleled synergy of personnel and/or product protection.

What Flow Sciences is adding to the mix is cost of ownership and return on investment. By utilizing intricate engineering and design into the construction of enclosure, they are able to achieve exceptional filter life. Airfoil and interior plenum innovation allows the company to match personnel protection with minimal interior powder deposition and optimal contaminant distribution across the filter surface.

Flow Sciences’ top-mounted fan design allows the filter to last for 4 to 5 years and prevents powder “recoil” back into the enclosure. A clean workspace means no cross-contamination. All of this means less downtime and more productivity!

With the Flow Sciences Advantage, you are able to enjoy the following features:

  • Ultra-micro-level Employee Protection: Flow Sciences’ team of scientists and engineers have proven powder concentration inside the enclosure to be as low as 0.0001 µg/m3.
  • User-oriented Ergonomic Design: Go/No-Go alarm, hinged doors, and input left/output right design promotes ease of use and maximized efficiency of work.
  • Balance Stability: Flow Sciences’ exhaust system design allows for consistent balance stability up to 6-7 decimal places.
  • Reduced energy costs: Even powder-deposition onto the primary HEPA filter results in consistently lower energy costs per billing period.
  • Lower cost of ownership: 4 to 5 year filter life, 4” pleated HEPA filters, and vibration reduction on the work surface yields an exceptionally low cost of ownership.

To learn more, visit: https://flowsciences.com/fsi-advantage/

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For a PDF of this Press Release or for questions or comments, please contact us below:

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About Flow Sciences, Inc.

Flow Sciences is the world’s leading developer of containment solutions for research and development laboratories, pilot plants, automation equipment and robotics, manufacturing and production facilities where toxic or noxious potent powders, fluids, or gases require safe handling while weighing, mixing, processing, or manufacturing. Since its start in the 1980s and with the introduction of the Vented Balance Safety Enclosure (VBSE™) in the 1990s, Flow Sciences has gone on to develop a comprehensive line of over 500 enclosures, including industry standards like the Vented Balance Safety Enclosure (VBSE™), the Contained Vented Bulk Powder Enclosure, and innovative laboratory technologies like the FS1501 Nitrogen Controller and the Bag-In/Bag-Out HEPA Filtration System. For its accomplishments, Flow Sciences received an Expert Achievement Award from the U.S. Department of Commerce for accomplishments in the global marketplace, the Deloitte and Touche North Carolina Technology Fast 50 Award, the UIBS R&D and Technology Collaboration Award, along with many others. During the 1990s, Flow Sciences pioneered the Vented Balance Safety Enclosure Series (VBSE™) which introduced the first independent fan exhaust system to isolate vibrations for balance accuracy, swiftly becoming the world leader in laboratory safety equipment. Flow Sciences technologies are now used to improve safety and containment in virtually every industrial sector around the globe, from pharmaceutical, food processing, robotics, chemical, forensics, agriculture, academia, infectious diseases, asbestos, tires, biotechnology, batteries, and nanotechnology. Flow Sciences has over 30 years of expertise in the development of containment solutions that deliver superior engineering quality and service at each level of controlled airflow containment systems. Flow Sciences offers the incorporation of Computational Fluid Dynamics (CFD), further refining the process of presenting personnel and product protection through framed enclosure solutions. The company’s Flow Sciences China division serves as a market leader in mainland China, spearheading the development of solutions throughout Asia. Under its Flow Sciences brand, Flow Sciences offers the best in laboratory containment, and is committed to finding containment solutions that meet your needs.

 

All other product names and trademarks are the property of their respective owners, which are in no way associated or affiliated with Flow Sciences.

 

Headquarters: Leland, NC USA:

Flow Sciences, Inc., 2025 Mercantile Drive, Leland, NC 28451;

Tel: 1-800-849-3429, Fax: 1-910-763-1220, Email: information@flowsciences.com,

Web: https://flowsciences.com/

 

Flow Sciences, Inc. Public Relations:

Jonathan Mann 2025 Mercantile Drive, Leland, NC 28451;

Tel: 1-910-332-4846 direct, Email: jmann@flowsciences.com,

Web: https://flowsciences.com


Flow Sciences' Bulk Powder Weighing Enclosures

PRESS RELEASE

Contact: Flow Sciences, Inc.

Tel: (800) 849-3429

Fax: (910) 763-1220

 

 

 

 FOR IMMEDIATE RELEASE

Flow Sciences’ Bulk Powder Weighing Enclosures

LELAND, NC, June 26, 2018 — Weighing powder from a 30-gallon drum? Flow Sciences, Inc. offers Bulk Powder Enclosures that are an effective system for bulk powder applications and large drum loading/unloading. The systems are available in several standard sizes, ranging from 4’ through 8’ exterior width.  A 20” diameter cut-out in the base allows for raising of the powder drum up and into the enclosure. This feature allows for safe weighing without interference stemming from data fluctuation or powder loss.

Bulk Powder Weighing Enclosures are shipped with 3 sizes of rubber membranes which can be cut to adapt to a wide variety of drums. To install, one simply pulls the membrane over the rim of the drum and installs a stainless steel ring to facilitate an air/powder leak-tight seal. Also available is a foot-controlled hydraulic lift (model 6551) which allows for ergonomic lifting of the drum up into the enclosure through the drum cut-out opening.

Results of Factory Acceptance Tests (FAT) and Site Acceptance Testing (SAT) have proven that Bulk Powder Weighing enclosures meet the performance requirements to retain containment below 1 microgram per cubic meter (μg/m³).  For more potent powders, a gloved Bulk Powder Hybrid Isolator is also available.

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For a PDF of this Press Release or for questions or comments, please contact us below:

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About Flow Sciences, Inc.

Flow Sciences is the world’s leading developer of containment solutions for research and development laboratories, pilot plants, automation equipment and robotics, manufacturing and production facilities where toxic or noxious potent powders, fluids, or gases require safe handling while weighing, mixing, processing, or manufacturing. Since its start in the 1980s and with the introduction of the Vented Balance Safety Enclosure (VBSE™) in the 1990s, Flow Sciences has gone on to develop a comprehensive line of over 500 enclosures, including industry standards like the Vented Balance Safety Enclosure (VBSE™), the Contained Vented Bulk Powder Enclosure, and innovative laboratory technologies like the FS1501 Nitrogen Controller and the Bag-In/Bag-Out HEPA Filtration System. For its accomplishments, Flow Sciences received an Expert Achievement Award from the U.S. Department of Commerce for accomplishments in the global marketplace, the Deloitte and Touche North Carolina Technology Fast 50 Award, the UIBS R&D and Technology Collaboration Award, along with many others. During the 1990s, Flow Sciences pioneered the Vented Balance Safety Enclosure Series (VBSE™) which introduced the first independent fan exhaust system to isolate vibrations for balance accuracy, swiftly becoming the world leader in laboratory safety equipment. Flow Sciences technologies are now used to improve safety and containment in virtually every industrial sector around the globe, from pharmaceutical, food processing, robotics, chemical, forensics, agriculture, academia, infectious diseases, asbestos, tires, biotechnology, batteries, and nanotechnology. Flow Sciences has over 30 years of expertise in the development of containment solutions that deliver superior engineering quality and service at each level of controlled airflow containment systems. Flow Sciences offers the incorporation of Computational Fluid Dynamics (CFD), further refining the process of presenting personnel and product protection through framed enclosure solutions. The company’s Flow Sciences China division serves as a market leader in mainland China, spearheading the development of solutions throughout Asia. Under its Flow Sciences brand, Flow Sciences offers the best in laboratory containment, and is committed to finding containment solutions that meet your needs.

 

All other product names and trademarks are the property of their respective owners, which are in no way associated or affiliated with Flow Sciences.

 

Headquarters: Leland, NC USA:

Flow Sciences, Inc., 2025 Mercantile Drive, Leland, NC 28451;

Tel: 1-800-849-3429, Fax: 1-910-763-1220, Email: information@flowsciences.com,

Web: https://flowsciences.com/

 

Flow Sciences, Inc. Public Relations:

Jonathan Mann 2025 Mercantile Drive, Leland, NC 28451;

Tel: 1-910-332-4846 direct, Email: jmann@flowsciences.com,

Web: https://flowsciences.com


Save Energy and Lab Space : Flow Sciences' Local Exhaust Ventilation Hoods

PRESS RELEASE

Contact: Flow Sciences, Inc.

Tel: (800) 849-3429

Fax: (910) 763-1220

 

 

 

 FOR IMMEDIATE RELEASE

Save Energy and Lab Space: Flow Sciences’ Local Exhaust Ventilation Hoods  

LELAND, NC, July 13, 2018 — Flow Sciences, a leading provider of containment systems for laboratory, pilot plant, and manufacturing is now shipping the LEV III™, an addition to its expanding line of standard enclosures.

This iconic new enclosure series uses a similar to design to their definitive powder containment enclosures and is developed for the removal of vapors from the application and lab. Vapors are pulled to the rear of the enclosure, then up through the plenums to keep laminar flow across the work surface and remove vapors effectively.

The enclosure is lightweight which makes it easily movable as the dynamics of the laboratory space changes. Whether you’re an R&D scientist, a laboratory manager, or a technician, you will benefit from the very best of efficient and effective containment, added energy savings, and the rich dynamic response of these authentic enclosures.

Flow Sciences LEV III™: Ideal for the following applications:

  • Flash Chromatography: Capped solvent storage space on the top of the LEV III™ maximizes laboratory space and simplifies work processes.
  • Rotary Evaporators: The interior height space of the LEV III™ is ideal for most rotary evaporators and increases operational efficiencies.
  • Microwave Digestion: Utility ports and efficient space saving technologies help establish the LEV III™ as the new standard in containment for microwave digestion.
  • Additive Manufacturing: This burgeoning industry now has the ideal source of containment, the LEV III™.
  • Oven Processes: Dry sensitive and toxic applications with ease.

Flow Sciences LEV III™ features:

  • Saves Energy and Lab Space by moving process applications out of fume hoods
  • Dished Phenolic Base
  • FS1650 Face Velocity Alarm
  • Portable Design
  • Clear Acrylic or Glass Walls
  • Turbulence Eliminating Front Airfoil
  • Dual Side Hinged Access Doors for easy sample loading and unloading
  • Hinged Front Sash for ease of operator interaction with equipment

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For a PDF of this Press Release or for questions or comments, please contact us below:

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About Flow Sciences, Inc.

Flow Sciences is the world’s leading developer of containment solutions for research and development laboratories, pilot plants, automation equipment and robotics, manufacturing and production facilities where toxic or noxious potent powders, fluids, or gases require safe handling while weighing, mixing, processing, or manufacturing. Since its start in the 1980s and with the introduction of the Vented Balance Safety Enclosure (VBSE™) in the 1990s, Flow Sciences has gone on to develop a comprehensive line of over 500 enclosures, including industry standards like the Vented Balance Safety Enclosure (VBSE™), the Contained Vented Bulk Powder Enclosure, and innovative laboratory technologies like the FS1501 Nitrogen Controller and the Bag-In/Bag-Out HEPA Filtration System. For its accomplishments, Flow Sciences received an Expert Achievement Award from the U.S. Department of Commerce for accomplishments in the global marketplace, the Deloitte and Touche North Carolina Technology Fast 50 Award, the UIBS R&D and Technology Collaboration Award, along with many others. During the 1990s, Flow Sciences pioneered the Vented Balance Safety Enclosure Series (VBSE™) which introduced the first independent fan exhaust system to isolate vibrations for balance accuracy, swiftly becoming the world leader in laboratory safety equipment. Flow Sciences technologies are now used to improve safety and containment in virtually every industrial sector around the globe, from pharmaceutical, food processing, robotics, chemical, forensics, agriculture, academia, infectious diseases, asbestos, tires, biotechnology, batteries, and nanotechnology. Flow Sciences has over 30 years of expertise in the development of containment solutions that deliver superior engineering quality and service at each level of controlled airflow containment systems. Flow Sciences offers the incorporation of Computational Fluid Dynamics (CFD), further refining the process of presenting personnel and product protection through framed enclosure solutions. The company’s Flow Sciences China division serves as a market leader in mainland China, spearheading the development of solutions throughout Asia. Under its Flow Sciences brand, Flow Sciences offers the best in laboratory containment, and is committed to finding containment solutions that meet your needs.

 

All other product names and trademarks are the property of their respective owners, which are in no way associated or affiliated with Flow Sciences.

 

Headquarters: Leland, NC USA:

Flow Sciences, Inc., 2025 Mercantile Drive, Leland, NC 28451;

Tel: 1-800-849-3429, Fax: 1-910-763-1220, Email: information@flowsciences.com,

Web: https://flowsciences.com/

 

Flow Sciences, Inc. Public Relations:

Jonathan Mann 2025 Mercantile Drive, Leland, NC 28451;

Tel: 1-910-332-4846 direct, Email: jmann@flowsciences.com,

Web: https://flowsciences.com


Isolator Containment Levels for a Fraction of the Cost

PRESS RELEASE

Contact: Flow Sciences, Inc.

Tel: (800) 849-3429

Fax: (910) 763-1220

 

 

 

 FOR IMMEDIATE RELEASE

Flow Sciences’ Hybrid Isolator Contains to Less Than 50 ng/mwith Bulk Powders 

LELAND, NC, June 26, 2018 — Flow Sciences, a leading provider of containment systems for laboratory, pilot plant, and manufacturing facilities, now offers a Bulk Powder Hybrid Isolator glovebox that is proven by third-party acceptance testing to facilitate an interior concentration of less than 50 nanograms per cubic meter (50 ng/m3).

 

The system maintains all of the engineering controls of the standard Hybrid Isolator, but is now designed to include a 20” cutout and a membrane set which can accommodate 3 bulk powder drum diameter sizes. The membrane set also prevents powder from spilling over the lip of the drum during pouring operations. In addition, it can be shipped with a hydraulic lifting jack which allows the customer to lift a drum through the base of the enclosure into its interior to work with the bulk powders in a contained environment.

Flow Sciences’ consultation process breeds innovative solutions, which drives the evolution of our standard products. This adaption of our Hybrid Isolator Series is a perfect example of who we are as a company. Every interaction with end users and engineers adds to our growing enclosure repertoire, which continues our corporate vision of providing the best containment solution for numerous applications. Using our TaskMatch application search tool, we combine today’s consumer-oriented market with our own expert consultation to create a product of optimal performance.

In the constantly connected landscape of today, the ever increasing toxicity of active pharmaceutical ingredients (APIs) presents the ever increasing need for personnel and/or product protection. At Flow Sciences, we consistently strive to ensure the safety of the whole process by engineering and manufacturing optimal enclosure. Flow Sciences creates engineering controls for hazards that cannot be eliminated or substituted.

For a PDF of this Press Release or for questions or comments, please contact us below:


Nitrogenema Glove Box

New Glove Box Controls
Relative Humidity or Oxygen Levels

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The NEW Nitrogenema™ Series of Glove Boxes from Flow Sciences, Inc. allow the user to purge Relative Humidity or Oxygen Levels down to ~2%.

These enclosures are capable of protecting the process by nearly eliminating moisture or oxygen with the flow of inert gas.

Safety of operator and process is accomplished with HEPA filtration, a one way check valve, and the ability to connect to a house exhaust system.

The Flow Sciences design uses AGS guidelines. The glove box is designed with a 28” depth and comfortable 10” oval glove ports which allow for minimized technician arm, wrist, and shoulder fatigue while maintaining a controlled environment.

The Nitrogen Metering System (FS1501) is designed to conserve nitrogen. It features trending graphs that display RH%, O2, and temperature. There are two adjustable flow rates one for high flow purge and the other for low flow to maintain. The nitrogen saving auto shut off activates when the set point of RH% or O2 is reached. Audio and visual alarms trigger when outside the set point range.

These Nitrogen Purge Glove Boxes are available in 3′ and 4′ widths and two exhaust options.

For complete specification and technical details go HERE

Flow Sciences, Inc. 
2025 Mercantile Drive
Leland, NC 28451 USA

email: info@FlowSciences.com
Website: www.FlowSciences.com
Telephone: 1-800-849-3429 or 1-910-763-1717


Contained Environmental Systems – from Flow Sciences

When it comes to keeping employees and equipment safe and laboratories or production lines hygienic, traditional vented enclosures and hoods are being challenged to provide increased protection for personnel working with the products produced within the workstation. Flow Sciences’ Contained Environmental Systems provide ideal environments for handling a variety of potent powders and mixtures from Active Pharmaceutical Ingredients (APIs) to carbon nanotubes and other nanomaterials, across the scope of laboratory, production line and research settings.

 

The Contained Environmental Systems line consists of four enclosure types that are ready for bench top applications in standard sizes; and can be customized to fit industry- or task-specific needs and standards. Each of these systems features ergonomically designed glove ports with Bag-In Bag-Out HEPA filtration (as appropriate) and come in a range of sizes to make maximum use of available bench top space.

 

Enclosures in the series include:

Temperature and Humidity Contained Environment (THCE)

Vented Atmosphere Contained Environment (VACE)

Controlled Atmosphere Contained Environment (CACE)

Hybrid Isolators – available in two configurations; one which uses make-up air from the room and the other which uses HEPA filtered make-up air.

 

THCE – Temperature and Humidity Contained Environment

The THCE features patented LFBC (Lateral Airflow Bio Containment) technology. A unique Bag-in/Bag-out HEPA filtration system protects employee breathing zones and prevents environmental contaminants from entering the chamber and keeps potent APIs, nanomaterials and other matter from exiting the chamber and causing health and safety concerns within the laboratory environment.

 

Flow’s design team not only considered safety when designing the THCE, but also employee comfort. Glove ports allow users to reach any part of the THCE while staying protected from potent powders, and LED lighting provides adequate in-chamber illumination with little heat and little energy use.

 

Included are a touch screen interface and data-logging software, both designed for ease of use and to accommodate a variety of data recording. A temperature and humidity sensor allows users to monitor in-chamber conditions and adjust them to the ideal conditions for work.

 

Flow Science’s THCE conforms to ASHRAE 110-95. Factory Acceptance Testing (FAT) is available to validate the performance and guarantee that each unit meets client containment standards.

 

VACE – Vented Atmosphere Contained Environment

The Vented Atmosphere Contained Environment from Flow Sciences features lateral airflow and in one configuration utilizes positive air pressure to reduce the risk of product contamination. Ideal for analysis and dosing of bottling liquid or solid APIs, handling nanomaterials, the VACE draws ambient room air through HEPA filters, providing a non-contaminated, gentle airflow across the work air.  Out-flowing HEPA filters prevent materials from contaminating the work surface environment.

 

VACE units are customizable to meet industry-specific needs and safety specifications. Options include stainless steel or phenolic work surfaces and various configurations of HEPA filters, and are available in a range of sizes and configurations designed to accommodate laboratory and production-line equipment. Glove ports are also available in a range of sizes.

 

Each VACE unit is equipped with glove ports and large acrylic windows to allow users to easily see and access the chamber while safely and comfortably completing work tasks, cleanup and routine maintenance. Alternate materials of construction along with Factory Acceptance Testing are available.

 

CACE – Controlled Atmosphere Contained Environment

CACE units allow operators to control the atmosphere within the chamber, creating the ideal low-oxygen or inert gas environments as their applications require. Inlet and purge valves make it easy to adjust the makeup of the atmosphere within the chamber, while pressure gauges and probe connections allow for effective monitoring of the chamber.

 

Each CACE unit features wide glove ports and can be made from a variety of materials including all-acrylic body construction and work surfaces made from stainless steel or chemically resistant phenolic with or without stainless steel insets.

 

 

Hybrid Isolator

As new, highly potent APIs and nanomaterials continue to enter the workplace, Flow Sciences Hybrid Isolators are available to ensure the safety and hygiene of workers and work environments. The hybrid isolator was designed to protect workers from exposure by fully-encompassing equipment and products used during research and development; weighing, loading and distributing powders; and other manufacturing processes. Ideal for powder handling, housing sensitive equipment and a host of other applications units are available for customer customization.

 

Hybrid Isolators are equipped with directional LED lighting, acrylic construction (for increased in-chamber visibility) and air plenums designed to ensure the proper air speed and flow within the chamber. Glove ports from 8”-10” provide workers with ample room for a comfortable work environment, and a removable face allows for easy instrumentation setup and teardown. Standard units come equipped with dual HEPA filters and Bag-In Bag-Out filtration and ante-chamber. Customizable to fit industry- and task-specific laboratory apparatus FAT and Surrogate Powder testing are available to ensure containment for the process.

 

Jason Frye produced this story with the assistance of Steve Janz, VP Marketing and Business Development for Flow Sciences Inc., which produces containment systems for laboratories, pilot plants and manufacturers. These products are designed to protect operators or product from exposure to hazardous particulates and vapors while performing delicate operations.


Sampling and Dosing Starts with Containment

When sampling and dosing active pharmaceutical ingredients (APIs) or high-potency APIs (HPAPIs), containment can be critical. Good laboratory practices (GLP) and the proper equipment designed and calibrated to facilitate GLP when transferring, mixing or blending APIs can reduce product waste, product contamination and minimize lost profit as well as create a healthier, contaminant free environment for lab operators.

 

Part of every lab’s GLP should be the utilization of contained environmental systems, fume hoods or specialty containment solutions designed to help control the mixing or blending environment, making it more suitable to the delicate task at hand. For powdered APIs, a controlled environment means one free of excess humidity, moisture and other contaminants. With liquid APIs, the best environment will be one free of the risk of contamination as well as the proper airflow within the enclosure that will not cause the APIs to evaporate to quickly.

 

The key to containment and control is airflow. With properly designed hoods and equipment enclosures, airflow within the unit will contain loose particles, allow liquids to evaporate at normal rates, pull hazardous fumes and particles away from the operator and into a safe disposal area. High quality hoods use face-opening airspeed that will safely contain particles within the unit and keep contaminants out while facilitating a good work environment for the operator, making for easier product handling by the operator while still offering maximum containment.

 

Traditional fume hoods require face-opening airspeeds at or exceeding 100 linear feet per minute (lfpm). That volume of air moving at such a high rate of speed will encourage liquids to evaporate quickly; disturb balances; cause powder loss from transport containers, mixing vessels and sampling tools; additionally, for equipment operators, the noise and speed of the air within the fume hoods can become exhausting and frustrating to work in.

 

Specialty hoods and enclosures can reduce the face velocity to 70-75 lfpm or lower, depending on the application, while lessening or even eliminating issues that come with mixing and blending API powders and liquids. By using hoods, enclosures and protected systems that incorporate lower wind speeds and engineered solutions that eradicate the hidden vortices, eddies and cross currents that disturb powders and hasten the evaporation of liquids, labs can better control their loss in material and operator time.

 

Protected systems are alternatives to clean rooms that incorporate a series of benchtop and freestanding units designed to enclose equipment for measuring, transporting, mixing and dispensing APIs and joined by sealed pass-through chambers can help lab operators exercise greater control over employee safety and final product quality. These joined, protected workstations allow laboratories to be configured in the most efficient way and minimize the necessity of bulky and uncomfortable pieces of personal protective equipment, allowing lab operators to be more comfortable and move more freely about the lab while remaining safe and unexposed to harmful APIs.

 

Jason Frye produced this story with the assistance of Flow Sciences Inc., which produces containment systems for laboratories, pilot plants and manufacturers. These products are designed to protect operators from exposure to hazardous particulates and vapors while performing delicate operations.

Contact Flow Sciences


Industry Trends: Risk MAAP Overview

Below is the second part of a conversation with George Petroka, Director of BioPharma/EHS Services at IES Engineers, about trends and changes he sees within the industry, specifically related to Risk MAAP assessments.

 

George Petroka: With so much pharma work going to contract manufacturers, [contract manufacturers] have to demonstrate they’re not getting cross contamination from your product to my product and they have to be able to show that. The Food and Drug Administration (FDA) or European Medicines Agency (EMA) wants to see [proof labs aren’t cross contaminating and causing safety risks for producers and end users] because of the potency or the fact that you’re dealing with certain therapeutic classes such as cytotoxics or if you have two hormones, one is male one is female, you want to keep them from mixing.

 

For a while there – 10-12 years ago – the industry was saying, “You need to build dedicated facilities [for one-run productions].” Even the regulatory agencies got in on it. That’s really expensive and restrictive. So, the International Society of Pharmaceutical Engineering’s containment committee said to the FDA, “This isn’t science based. We have to be able to show scientifically that you need these proved segregations [of pharmaceutical components].”

 

So they put together this document, Risk MAAP. It came up with a couple of things, the most important of which was defining standard methodology for cleaning verification because all across pharma, we used different methodologies; we used 1/1000 of the Acceptable Daily Intake (ADI), LOD (Limit of detection), we used 10 parts per million, which was just arbitrary. Or you’d use visual, which meant, if you can see it, you’ve got a lot there.

 

So that was the first thing, come up with a standard methodology. It’s an ADI, but they called it an ADE – Acceptable Daily Exposure. It’s like setting an OEL. You use a “No observed effect level” then you apply safety factors. The safety factors are different than in an occupational setting because you’re looking a broad population – elderly and children versus worker population – and you’re not usually compromised (?)[4:45] so you’re safety factors are higher and your numbers (Average Daily Exposure (ADE)/ADI) are lower. The ADE is usually micrograms per day.

 

That pretty much stays with the compound the way an Observed Effect Level does. Except you do base it on the dosage form. An ADE would be different for solid dosage than for parenteral (injectable). With the solid dose you have a built in safety factor of taking something orally versus injecting it directly

 

Question: So, once you’ve determined your ADI, what then?

 

George Petroka: So you come up with that number, then you look at the manufacturing process. Am I making a solid dose, am I making a tablet? Then you look at the batch size, number of batches and surfaces you want to clean. You put those numbers into a calculation along with your ADE and you come up with a clean limit. Cleaning limit for something with 10kg would be different from 100g. You have much greater potential for exposure. You then have a good, scientifically based cleaning limit that you then can use to evaluate your potential cross contamination.

 

Cross contamination comes from airborne – not so much airborne actually, but it’s one method – mechanical, where you get it on surfaces, that’s the one they’re really concerned with; product mix up, again that can be managed through bar coding.

 

You do all that then do a failure mode and effect analysis to evaluate your risk level by getting a number.

 

Where Flow Sciences come in, by doing certain levels of containment and establishing certain containment controls, particularly containing at the source, you control and reduce your risk potential for cross contamination. So, you don’t have to build a full facility [for one product run]. It’s better, obviously, like occupational, for cross contamination, it gives you a control at the source, lower cost, less impact.

 

Jason Frye produced this story with the assistance of Flow Sciences Inc., which produces containment systems for laboratories, pilot plants and manufacturers. These products are designed to protect operators from exposure to hazardous particulates and vapors while performing delicate operations.

Contact Flow Sciences